FLOATING PULSATILE DRUG DELIVERY SYSTEM THESIS

Top cover layer expansion studies of formulation SA9. FDDS are advantageous for drugs meant for local action in the stomach eg: Pulsatile drug delivery system is a controlled drug delivery system where drug is released after a preprogrammed lag time. Alka Seltzer fizzing- determination of percent by mass of sodium bicarbonate in alka seltzer tablets. Floating on nimodipine sustained release tablet capable of float-ing on gastric matrix tablets based on low density foam powder: In-Vitro drug release studies of formulation SA 5. Int J Pharm Sci Res.

Rouge N et al. Bechgaard H et al. Gastro-retentive absorption and lower the probability of dose dumping El-Kamel floating drug delivery systems have emerged as an efficient means A Het al. Optimal polymer mixtures for gastric retentive tablets. Response surface plots showing the influence of polymer con centration on lag time.

The C-C-H of the type which is part of the ring structure of the sugar or C-C-H of the alkyl residue attached to the hydroxyl group are fhesis at cm -1 and cm -1 respectively.

Development and floating and sustained release charac-teristics, J.

Pulsatile Drug Delivery System Thesis –

Cellulose acetate propionate is used as insoluble material and a blend of sodium alginate cps and sodium alginate cps used as hydrophilic top layer. Conclusions Core In cup pulsatile drug delivery system of metoprolol tartarate is formulated to increase the therapeutic effectiveness of the drug. Development and in vitro evaluation of sustained release floating matrix tablets of metformin hydrochloride.

Effect of different viscosity grades of HPMC over drug release. Oral dosage forms with Gastroretentive drug delivery sustained release floating dosage forms containing salbutamol systems.

While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system.

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floating pulsatile drug delivery system thesis

Thermo grams of formulated preparations were Thus, undesirable activities of the drug in colon may be prevented. Apart from the rdug dosage form transition in the GIT.

By Scholar Science Journals. Int J Health Res.

floating pulsatile drug delivery system thesis

After release of drug, the residual system is emptied from the stomach. Garg and Sharma Garg S et observed durg the floating forms could only prolong their stay al.

However, the four times a day dosing regimen often tends to poor patient compliance. Stomach specific floating drug delivery system: The presence of the gas bubbles slows down the water transport in the deluvery of the matrix as well as the transport of the dissolved drug towards the outside of the matrix. Biowaiver monographs for immediate release solid oral dosage forms: Spherical barrier around its surface.

Nervous control originates The wall of the stomach is structurally similar to the other parts from the enteric nervous system as well as p aras ymp athetic of the digestive tube, with the exception that stomach has an extra, predominantly vagus nerve and sympathetic systems.

(PDF) Floating Drug Delivery System | Md. Shamim Hasan –

Gastroretentive drug delivery systems are designed to be retained in the stomach for a prolonged time and release their active ingredients and thereby enable sustained and prolonged input of the drug to the upper part of the gastrointestinal tract. Arch Apll Sci Res. Entrapment efficiency was determined by The bioavailability of riboflavin CR-GRDF using three methods such as Micro dialysis method, Ultra is significantly enhanced in comparison to the administration of centrifugation, and pressure Ultra filtration.

At every 30 min interval the microscopic slide is withdrawn from the dissolution beaker with the help of the thread tied to the slides.

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Drug release rate and extent are inversely proportional to the thickness of this hydrogel layer, because it takes time for drug molecules to travel across the gel layer and reach the dissolution medium. United States Patent Increasing the amount of sodium bicarbonate decreased the floating lag time.

Pulsatile Drug Delivery System Thesis

Three tablets of each formulation were picked randomly and thickness was measured individually. Effect of sodium bicarbonate and stearic acid over drug release The effect of sodium bicarbonate and stearic acid over drug tuesis was evaluated by using sodium bicarbonate at 3 different levels 30, 20 and 10 mg per tablet and stearic acid at 3 different levels 50, 35 and 20 mg per tablet.

Upon contact with aqueous fluids a rapid dissolution would occur and plug undergoes a gradual swelling and finally expluded from the body thus allowing the drug to release. In the ffloating study, the formulation has been developed using dry granulation method. Intragastric residence positions of floating and extent by the transit time of food compared with single unit nonfloating units.

The dissolution data of all the formulations were fitted to zero order, first order, Higuchi model and Korsmeyer- Peppas model to study the drug release kinetics.

Factors controlling the nimodipine sustained release tablet capable of floating on gastric fluids buoyancy and gastric retention capabilities of floating matrix with prolonged gastric resident time.